Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors
نویسندگان
چکیده
منابع مشابه
Self-immolative phthalate esters sensitive to hydrogen peroxide and light.
Self-immolative aryl phthalate esters were conjugated with cleavable masking groups sensitive to light and hydrogen peroxide. The phthalate linker releases the fluorescent dye 7-hydroxycoumarin upon exposure to light or H2O2, respectively, leading to an increase in fluorescence. The light-sensitive aryl phthalate ester is demonstrated as a pro-fluorophore in cultured S2 cells.
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2011
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c1cc12526e